For any organism that has been domesticated, usually as pets or farm animals.
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- Sableye
- Sahonachelys
- Salawa
- Salish Wool Dog
- Sandshrew
- Sandslash
- SciiFii bee
- Sciifiiraptor
- Sciifiisaurus
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- Seal turkey
- Sentret
- Shagger
- Sicilian dwarf elephant
- Sinoconodon
- Snorkasaurus
- Snuffleupagus
- Sparrot
- Squibbon
- St Kilda house mouse
- St. John’s Water Dog
- Stitch
- Sumxu
- Sweetener melon
- Swoobat
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